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CAS No.: 14255-87-9

Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate Catalog No. CSN25428

Synonyms: SKF 29044;PBZ;PBZ (fungicide)

Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.

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描述Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity^[4]. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC50 of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells^[5]. Parbendazole (up to 10 μM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 μM) potently inhibits tubulin purified from the wild-type myxamoebae^[6]. Parbendazole causes profound cytoskeletal changes including degradation of microtubules and increased focal adhesions. Stabilization of microtubules by pretreatment with Taxol inhibits osteoblast differentiation. Parbendazole up-regulates bone morphogenetic protein 2 (BMP-2) gene expression and activity^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0438 mL
- 20.2189 mL
- 40.4379 mL
- 5 mM
- 0.8088 mL
- 4.0438 mL
- 8.0876 mL
- 10 mM
- 0.4044 mL
- 2.0219 mL
- 4.0438 mL

技术信息

CAS号

14255-87-9

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H17N3O2

运输

蓝冰

分子量

247.29

别名

SKF 29044;PBZ;PBZ (fungicide);Helatac;Helmatac

溶解度

DMSO	3.0 mg/mL (12.1 mM)
Water	Insoluble
Ethanol	Insoluble

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Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate Catalog No. CSN25428

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